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  • TUDCA

    TUDCA (tauroursodeoxycholic acid) is a water-soluble bile acid that occurs naturally in small amounts in the body. As a supplement, it's gaining attention in the nootropic community for its potential cognitive enhancing properties and neuroprotective effects. TUDCA may support brain health by reducing cellular stress, protecting neurons, and potentially improving cognitive function.

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    • TUDCA (tauroursodeoxycholic acid) is a water-soluble bile acid that occurs naturally in small amounts in the body. As a supplement, it's gaining attention in the nootropic community for its potential cognitive enhancing properties and neuroprotective effects. TUDCA may support brain health by reducing cellular stress, protecting neurons, and potentially improving cognitive function.
      1. Neuroprotective Effects: TUDCA has demonstrated protective properties against neuronal cell death in various models of neurodegenerative diseases, including Alzheimer's and Parkinson's disease. It helps stabilize mitochondrial function and reduces oxidative stress in brain cells
      2. Reduction of Inflammation and Oxidative Stress: Inflammation and oxidative stress are significant factors in cognitive decline and brain aging. TUDCA has anti-inflammatory properties and can decrease the production of pro-inflammatory cytokines, which helps mitigate neuroinflammation—a key factor in many brain-related conditions
      3. Mitochondrial Function Enhancement: TUDCA may support mitochondrial function in brain cells, potentially improving energy production and overall cognitive performance.
      4. Potential to Enhance Cognitive Function: Some studies suggest that TUDCA may improve cognitive function by promoting neuronal health and resilience against stressors that contribute to cognitive decline.
      5. Crosses the Blood-Brain Barrier: As one of the more hydrophilic bile acids, TUDCA can easily cross the blood-brain barrier, allowing it to exert its effects directly on the central nervous system.
      6. Amyloid-Beta and Tau Protein Modulation: TUDCA has been studied for its effects on amyloid-beta and tau proteins, which are central to the pathology of Alzheimer's disease. It can reduce the aggregation of these proteins and promote their clearance, potentially slowing disease progression and preserving cognitive function.
      7. Support for Metabolic Health: By improving insulin sensitivity and metabolic function, TUDCA may indirectly support brain health, as metabolic disorders are linked to cognitive decline.
    • Usage Amount Frequency Notes
      Standard 250mg 2 times daily Water-soluble nootropic
      Intensive 500mg 2 times daily Same as above
      1. TUDCA (Examine)
      2. TUDCA Potential Uses, Side Effects & Reviews (SelfDecode)
      3. What Is TUDCA, What are its Benefits, & Why Does it Matter for My Health? (BodyBio)
      4. Tauroursodeoxycholic Acid (TUDCA) (AlzDiscovery)